Etiology of Diabetes mellitus in Dogs

Potential Diabetes mellitus

Potential Diabetes mellitus is defined as impaired insulin synthesis or secretion and/or decreased sensitivity of receptors to the effects of insulin. Hyperglycemia is seen.

Increased blood glucose concentration that does not yet exceed the renal threshold can be seen in intact bitches during metoestrus. This may be reversible by spaying (removal of the progesterone source).

Hyperglycemia may also be encountered in Cushing’s syndrome (hyperadrenocorticism); reversal of the cortisol excess may prevent the development of Diabetes mellitus.

Canine Diabetes mellitus

Canine diabetes mellitus can originate from: